Dr. John Tine

RSC Mueller Science 105
518-244-2291
[email protected]

Bio / History

Dr. John Tine is a lecturer in the Department of Biology and Health Sciences. He completed his Ph.D. in microbiology and immunology at Albany Medical College where he studied the genetic evolution of major histocompatibility complex genes in wild mice. Dr. Tine has extensive research experience as a post-doctoral fellow and research scientist at Virogenetics Corporation where he utilized poxvirus vector systems to develop vaccine candidates for the human malaria parasite Plasmodium falciparum and immunotherapies for human melanoma and colorectal cancers. He then moved to the University at Albany, where he directed the Molecular Biology Laboratory at the Center for Functional Genomics and played a major role in the development and implementation of an undergraduate major in Bioinstrumentation at the University’s School of Public Health. Dr. Tine’s current research interests include the structure of multidrug-resistance plasmids in bacteria and the molecular biology of RNA viruses in plants.

Courses I like to teach include:

  • Anatomy and Physiology
  • Microbiology
  • Research Methods

Selected Publications

Felker, P., Bunch, R., Tine, J.A., Russo, G.R., Gould, J., Arnold, M., Wang, F., Rong, Y., and Wright, M. 2018. Stable Transformation of Opuntia ficus indica Callus Cultures as Evidenced by Fluorescence of the Tandem Dimer Tomato Gene. Journal of the Professional Association for Cactus Development 20, 34-51.

Preston, K.E., and Tine, J.A. 2017. Acquisition of a Second Multi-Drug Resistance-Encoding Element by IncM1 Plasmid pACM130 Abolished Conjugative Transfer. Plasmid 92, 26-29.

Preston, K.E., Hitchcock, S.A., Aziz, A.Y., and Tine, J.A. 2014. The Complete Nucleotide Sequence of the Multi-Drug Resistance-Encoding IncL/M Plasmid pACM1. Plasmid 76, 54-65.

Avasarala, J.R., Chittur, S.V., George, A.D. and Tine, J.A. 2008. Microarray Analysis in B Cells Among Siblings With and Without MS – Possible Role for Transcription Factor TCF2. BMC Medical Genomics 1,2.

Eifert, C, Sangster-Guity, N, Yu, L.M., Chittur, S.V., Perez, A.V., Tine, J.A., and McCormick, P.J. 2006. Global Gene Expression Profiles Associated with Retinoic Acid-induced Differentiation of Embryonal Carcinoma Cells. Molecular Reproduction and Development 73, 796-824.

Li, L., Pan, R.M., Porter, T.D., Jensen, N.S., Silber, P., Russo, G, Tine, J.A., Heim, J, Ring, B, and Wedlund, P.J. 2006. New Cytochrome P450 2D6*56 Allele Identified by Genotype/Phenotype Analysis of Cryopreserved Human Hepatocytes. Drug Metabolism and Disposition 34, 1411-1416.

Tine, J.A., Firat, H., Payne, A., Russo, G., Davis, S.W., Tartaglia, J., Lemonnier, F., Langlade Demoyen, P., and Moingeon, P. 2005. Enhanced Multiepitope-based Vaccines Elicit CD8+ Cytotoxic T Cells Against Both Immunodominant and Cryptic Epitopes. Vaccine 23, 1085-1091.

Rogers, W.O., Weiss, W.A., Kumar, A., Aguiar, J.C., Tine, J.A., Gwadz, R., Harre, J.G., Gowda, K., and Hoffman, S.L. 2002. Protection of Rhesus Macaques Against Lethal P. knowlesi Malaria by a Heterologous DNA Prime/Poxvirus Boost Immunization Regimen. Infection and Immunity 70, 4329-4335.

Rogers, W.O., Baird, J.K., Kumar, A., Tine, J.A., Weiss, W.R., Aguiar, J.C., Gowda, K., Gwadz, R.W., Kumar, S., Gold, M., and Hoffman, S.L. 2001. Multi-Stage, Multi-Antigen, Heterologous Prime Boost Vaccine for Plasmodium knowlesi Malaria Provides Partial Protection in Rhesus Macaques. Infection and Immunity 69, 5565-5572.

Schultz, E.S., Zhang, Y., Knowles, R., Tine, J., Traversari, C., Boon, T., and van der Bruggen, P. 2001. A MAGE-3 Peptide Recognized on HLA-B35 and HLA-A1 by Cytolytic T Lymphocytes. Tissue Antigens 57, 103-109.

Horig, H., Lee, D.S., Conkright, W., Divito, J., Hasson, H., LaMare, M., Rivera, A., Park, D., Tine, J., Guito, K., Tsang, K.W., Schlom, J., and Kaufman, H.L. 2000. Phase I Clinical Trial of a Recombinant Canarypoxvirus (ALVAC) Vaccine Expressing Human Carcinoembryonic Antigen and the B7.1 Co-Stimulatory Molecule. Cancer Immunology and Immunotherapy 49, 504-514.

Sutmiller, R.P.M., Schurmans, L.R.H.M., Tine, J.A., van der Voort, E.I.H., Melief, C.J.M., Jager, M.J., and Offringa, R. 2000. Adoptive T Cell Immunotherapy of Human Uveal Melanoma Targeting gp100. Journal of Immunology 165, 7308-7315.

Luiten, R.M., Demotte, N., Tine, J., and van der Bruggen, P. 2000. A MAGE-A1 Peptide Presented to Cytolytic T Lymphocytes by Both HLA-B35 and HLA-A1 Molecules. Tissue Antigens 56, 77-81.

Sedegah, M., Weiss, W., Sacci, J.B., Charoenvit, Y., Hedstrom, R., Gowda, K., Majam, V.F., Tine, J., Kumar, S., Hobart, P., and Hoffman, S.L. 2000. Improving Protective Immunity Induced by DNA-Based Immunization: Priming with Antigen and GM-CSF Encoding Plasmid DNA and Boosting with Antigen Expressing Recombinant Poxvirus. Journal of Immunology 164, 5905-5912.

Sedegah, M., Jones, T.R., Kaur, M., Hedstrom, R., Hobart, P., Tine, J.A., and Hoffman, S.L. 1998. Boosting with Recombinant Vaccinia Increases Immunogenicity and Protective Efficacy of a Malaria DNA Vaccine. Proceedings of the National Academy of Sciences USA 95, 7648-7653.

Ockenhouse, C.F., Sun, P.F., Lanar, D.E., Wellde, B.T., Hall, B.T., Kester, K., Stoute, J., Magill, A., Kryzch, U., Farley, L., Wirtz, R.A., Sadoff, J.C., Kaslow, D.C., Kumar, S., Church, L.W.P., Crutcher, J.M., Wizel, B., Hoffman, S., Lalvani, A., Hill, A.V.S., Tine, J.A., Guito, K.P., de Taisne, C., Anders, R., Horii, T., Paoletti, E., and Ballou, W.R. 1998. Phase I/IIa Safety, Immunogenicity, and Efficacy of NYVAC-Pf7, a Pox-Vectored, Multiantigen, Multistage Vaccine Candidate for Plasmodium falciparum Malaria. Journal of Infectious Diseases 177, 1664-1673.

Tine, J.A., Lanar, D.E., Smith, D.M., Wellde, B.T., Schultheiss, P., Ware, L.A., Kauffman, E.B., Wirtz, R.A., de Taisne, C., Hui, G.S.N., Chang, S.P., Church, P., Kaslow, D.C., Hoffman, S., Guito, K.P., Ballou, W.R., Sadoff, J.C., and Paoletti, E. 1996. NYVAC-Pf7: A Poxvirus-Vectored, Multiantigen, Multistage Vaccine Candidate for Plasmodium falciparum Malaria. Infection and Immunity 64, 3833-3844.

Lanar, D.E., Tine, J.A., de Taisne, C., Seguin, M.C., Cox, W.I., Winslow, J.P., Ware, L.A., Kauffman, E.B., Gordon, D., Ballou, W.R., Paoletti, E., and Sadoff, J.C. 1996. Attenuated Vaccinia Virus-Circumsporozoite Protein Recombinants Confer Protection Against Rodent Malaria. Infection and Immunity 64, 1666-1671.

Tine, J.A., de Taisne, C., Conseil, V., Delplace, P., Camus, D., and Paoletti, E. 1992. Immunogenicity of the Plasmodium falciparum Serine Repeat Antigen (p126) Expressed by Vaccinia Virus. Infection and Immunity 61, 3933-3941.

Tine, J.A., Walsh, A., Rathbun, D., Leonard, L., Wakeland, E.K., Dilwith, R., and Flaherty, L. 1990. Genetic Polymorphisms of Q Region Genes from Wild-derived Mice: Implications for Q Region Evolution. Immunogenetics 31, 315-325.